Payments by PayPal are being introduced on the Flybe website.
Users booking flights online can use the system to pay in sterling, euros or US dollars.
The introduction of PayPal means the airline can attract consumers who either do not have, or dislike using, credit or debit cards, Flybe said.
It also streamlines the booking process by reducing the amount of clicks needed to move through the booking process.
The airline’s chief commercial officer Paul Simmons said: “We want to make booking as quick and easy as possible for all our customers no matter in what currency they are paying, and PayPal does just that by giving them the ability to pay the way they want to pay.
“We understand that millions of people these days have PayPal accounts and that they often prefer using this payment method when paying and we sincerely hope that this will prove of great benefit to them.”
PayPal UK managing director Cameron McLean added: “Our customers love travelling and we’re sure they’ll be quick to take advantage of the fact it’s now even faster to pay for a flight with Europe’s biggest regional airline.
"We’ve been very impressed at how quickly Flybe moved to add PayPal to its website – one of the fastest arrivals we’ve seen.”